کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2847252 1167344 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regional pulmonary inflammation in an endotoxemic ovine acute lung injury model
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Regional pulmonary inflammation in an endotoxemic ovine acute lung injury model
چکیده انگلیسی

The regional distribution of inflammation during acute lung injury (ALI) is not well known. In an ovine ALI model we studied regional alveolar inflammation, surfactant composition, and CT-derived regional specific volume change (sVol) and specific compliance (sC). 18 ventilated adult sheep received IV lipopolysaccharide (LPS) until severe ALI was achieved. Blood and bronchoalveolar lavage (BAL) samples from apical and basal lung regions were obtained at baseline and injury time points, for analysis of cytokines (IL-6, IL-1β), BAL protein and surfactant composition. Whole lung CT images were obtained in 4 additional sheep. BAL protein and IL-1β were significantly higher in injured apical vs. basal regions. No significant regional surfactant composition changes were observed. Baseline sVol and sC were lower in apex vs. base; ALI enhanced this cranio-caudal difference, reaching statistical significance only for sC. This study suggests that apical lung regions show greater inflammation than basal ones during IV LPS-induced ALI which may relate to differences in regional mechanical events.


► We study regional inflammation and CT-derived specific compliance in an ALI model.
► IV LPS significantly increases alveolar and plasma cytokines.
► Lung apex shows greater alveolar protein and IL-1β and lower specific compliance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 183, Issue 2, 15 August 2012, Pages 149–158
نویسندگان
, , , , , , ,