کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2847272 1167347 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Altered aquaporins in the brains of mice submitted to intermittent hypoxia model of sleep apnea
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Altered aquaporins in the brains of mice submitted to intermittent hypoxia model of sleep apnea
چکیده انگلیسی

Rostral fluid displacement has been proposed as a pathophysiologic mechanism of both central and obstructive sleep apnea. Aquaporins are membrane proteins that regulate water transport across the cell membrane and are involved in brain edema formation and resolution. The present study investigated the effect of intermittent hypoxia (IH), a model of sleep apnea, on brain aquaporins.Mice were exposed to intermittent hypoxia to a nadir of 7% oxygen fraction. Brain water content, Aquaporin-1 and Aquaporin-3 were measured in the cerebellum and hippocampus. Hematoxylin–eosin and immunohistochemistry stainings were performed to evaluate cell damage.Compared to the sham group, the hypoxia group presented higher brain water content, lower levels of Aquaporin-1 and similar levels of Aquaporin-3. Immunoreactivity to GFAP and S100B was stronger in the hypoxia group in areas of extensive gliosis, compatible with cytotoxic edema.These findings, although preliminary, indicate an effect of IH on aquaporins levels. Further investigation about the relevance of these data on the pathophysiology of OSA is warranted.


► Intermittent hypoxia affects the expression of brain aquaporins.
► Mice exposed to intermittent hypoxia presented increased brain water content.
► Aquaporins might play a role in the pathophysiology of sleep apnea syndromes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 185, Issue 2, 15 January 2013, Pages 217–221
نویسندگان
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