کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2847283 1167347 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Augmented breaths (‘sighs’) are suppressed by morphine in a dose-dependent fashion via naloxone-sensitive pathways in adult rats
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Augmented breaths (‘sighs’) are suppressed by morphine in a dose-dependent fashion via naloxone-sensitive pathways in adult rats
چکیده انگلیسی

Morphine treatment can eliminate augmented breaths (ABs; ‘sighs’) during spontaneous breathing. In the present study, unanesthetized rats were studied to: (1) determine the involvement of naloxone-sensitive receptor pathways, and (2) establish the dose–response relationship of this side effect. At a dosage of 5 mg/kg (2–10 mg/kg is recommended range for analgesia) morphine eliminated ABs from the breathing rhythm across nearly 100 min post-administration (vs. 6.2 ± 1.6 ABs in 15 min, control condition, p < 0.001). This occurred despite no apparent effect on indices of ventilation. By contrast, when naloxone was co-administered with morphine, the occurrence of ABs was not different compared to control. The suppression of ABs by morphine followed a sigmoidal pattern across the low–mid dosage range (R2 = 0.83), whereas tidal volume and breathing frequency were unaffected. We conclude that the opioid-induced suppression of ABs is mediated by naloxone-sensitive opioid receptor pathways, and that this side effect is potent across the low–mid dosage range, and cannot be simply avoided by restricting dosage.


► Morphine suppresses the spontaneous production of augmented breaths (ABs).
► This effect follows a sigmoidal dose–response pattern across low–mid dosages.
► The generation of ABs is exquisitely sensitive to opioid drugs compared to eupnea.
► The effect is prevented by naloxone, thus occurring via opioid receptor-based pathways.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 185, Issue 2, 15 January 2013, Pages 296–303
نویسندگان
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