کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2847347 1167353 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hypercapnia attenuates inspiratory amplitude and expiratory time responsiveness to hypoxia in vagotomized and vagal-intact rats
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Hypercapnia attenuates inspiratory amplitude and expiratory time responsiveness to hypoxia in vagotomized and vagal-intact rats
چکیده انگلیسی

A negative influence of central chemosensitivity on peripheral chemoreflex response has been demonstrated recently in a decerebrate-vagotomized rat preparation in situ with separate carotid body and brainstem perfusions. Here, we report similar negative influences of hypercapnia on the hypoxic respiratory response in anesthetized, spontaneously breathing rats before and after vagotomy and anesthetized, artificially ventilated rats after vagotomy. Baseline breathing patterns and responsiveness to hypercapnia and hypoxia varied widely between the three respiratory modes. Despite this, the responses in inspiratory amplitude and expiratory duration (and hence respiratory frequency and neural ventilation) to hypoxia varied inversely with the background CO2 level in all three groups. Results demonstrate a hypoadditive hypercapnic–hypoxic interaction in vivo that resembles the hypoadditive central–peripheral chemoreceptor interaction in situ for these respiratory variables in the rat, regardless of differences in vagal feedback, body temperature and ventilation method. These observations stand in contrast to previous reports of hyperadditive peripheral-central chemoreceptor interaction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 181, Issue 1, 15 April 2012, Pages 79–87
نویسندگان
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