کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2847536 1167372 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mitochondrial complex III: An essential component of universal oxygen sensing machinery?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Mitochondrial complex III: An essential component of universal oxygen sensing machinery?
چکیده انگلیسی

Oxygen is necessary for the survival of mammalian cells. In order to maintain adequate cellular oxygenation, mammals have evolved multiple acute and long-term adaptive responses to hypoxia. These include hypoxic increases in erythropoiesis, pulmonary vasoconstriction and carotid body neurosecretion. Collectively, these responses help maintain oxygen homeostasis as oxygen levels remain scarce. There are multiple effectors proposed to underlie these diverse responses to hypoxia including PHD2, AMPK, NADPH oxidases, and mitochondrial complex III. Here I propose a model wherein complex III is integral to oxygen sensing in regulating diverse response to hypoxia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 174, Issue 3, 31 December 2010, Pages 175–181
نویسندگان
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