کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2847629 1167378 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cerebellar 5HT2A receptor function under hypoxia in neonatal rats: Role of glucose, oxygen, and epinephrine resuscitation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Cerebellar 5HT2A receptor function under hypoxia in neonatal rats: Role of glucose, oxygen, and epinephrine resuscitation
چکیده انگلیسی

Molecular processes regulating the cerebellar serotonergic receptors play an important role in the control of respiration and cognitive functions under hypoxia. The present study examined cerebellar 5HT receptor alterations and neuroprotective effect of glucose supplementation prior to current sequence of resuscitation—oxygen and epinephrine supplementation in hypoxic neonatal rats. Hypoxic stress increased the number of total 5HT and 5HT2A receptors along with an up-regulation of 5HT transporter and 5HT2A receptor gene in cerebellum. These serotonergic alterations were reversed to near control by glucose supplementation. Immunohistochemical studies confirmed the data. Behavioral studies revealed the cognitive impairment due to neonatal hypoxia in the later stages of life and the role of timely glucose supplementation in preventing these behavioral deficits. The enhanced cerebellar 5HT2A receptors may act as a modulator of ventilatory response to hypoxia, which can in turn result in cognitive dysfunction. Glucose supplementation helped in managing the serotonergic functional alterations. This has immense clinical significance in neonatal care.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 172, Issue 3, 31 July 2010, Pages 147–153
نویسندگان
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