کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2847648 | 1167379 | 2010 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Blood gases and cardiovascular shunt in the South American lungfish (Lepidosiren paradoxa) during normoxia and hyperoxia Blood gases and cardiovascular shunt in the South American lungfish (Lepidosiren paradoxa) during normoxia and hyperoxia](/preview/png/2847648.png)
The South American lungfish (Lepidosiren paradoxa ) has an arterial PO2PO2 (PaO2PaO2) as high as 70–100 mm Hg, corresponding to Hb–O2 saturations from 90% to 95%, which indicates a moderate cardiovascular right to left (R–L) shunt. In hyperoxia (50% O2), we studied animals in: (1) aerated water combined with aerial hyperoxia, which increased PaO2PaO2 from 78 ± 2 to 114 ± 3 mm Hg and (2) and aquatic hyperoxia (50% O2) combined room air, which gradually increased PaO2PaO2 from 75 ± 4 mm Hg to as much as 146 ± 10 mm Hg. Further, the hyperoxia (50%) depressed pulmonary ventilation from 58 ± 13 to 5.5 ± 3.0 mL BTPS kg h−1, and PaCO2PaCO2 increased from 20 ± 2 to 31 ± 4 mm Hg, while pHa became reduced from 7.56 ± 0.03 to 7.31 ± 0.09. At the same time, venous PO2PO2 (PvO2PvO2) rose from 40.0 ± 2.3 to 46.4 ± 1.2 mm Hg and, concomitantly, PvCO2PvCO2 increased from 23.2 ± 1.1 to 32.2 ± 0.5 mm Hg. R–L shunts were estimated to about 19%, which is moderate when compared to most amphibians.
Journal: Respiratory Physiology & Neurobiology - Volume 173, Issue 1, 31 August 2010, Pages 47–50