کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2847783 1167389 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of Locus coeruleus noradrenergic neurons in cardiorespiratory and thermal control during hypoxia
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Role of Locus coeruleus noradrenergic neurons in cardiorespiratory and thermal control during hypoxia
چکیده انگلیسی

We investigated the specific role of LC noradrenergic (NA) neurons in the cardiorespiratory and thermal responses to hypoxia. Aiming this, LC NA neurons were selectively destroyed by microinjecting 6-OHDA bilaterally in the LC of male rats. Pulmonary ventilation (V˙E, plethysmograph), core body temperature (Tc, dataloggers), mean arterial pressure (MAP) and heart rate (fH) were measured during normoxia followed by 7% O2 in air. Tyrosine hydroxylase (TH) immunoreactivity was performed to verify the chemical lesions effectiveness. Hypoxia caused increase in V˙E, decrease in Tc and did not affect fH in both sham-operated and 6-OHDA-lesioned groups. In addition, hypoxia decreased MAP in the sham-operated group and did not affect MAP in the 6-OHDA-lesioned group. LC lesion did not affect V˙E, MAP, fH and Tc. Thus, these results indicate that LC noradrenergic neurons do not play a role in cardiorespiratory control and thermoregulation under basal and hypoxic conditions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 170, Issue 2, 28 February 2010, Pages 150–156
نویسندگان
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