کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2847925 1167396 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Attenuated phrenic long-term facilitation in orexin neuron-ablated mice
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Attenuated phrenic long-term facilitation in orexin neuron-ablated mice
چکیده انگلیسی

We examined phrenic long-term facilitation (LTF) in urethane-anesthetized, vagotomized, paralyzed, and artificially ventilated orexin neuron-ablated mice and their wild-type littermates. Effect of isocapnic single hypoxic episode (SHE, for 45 s) and intermittent hypoxia (IH, 5 times of SHE separated by 5 min) on phrenic nerve activity (PNA) was measured for 1–2 h. In wild-type mice, amplitude of PNA gradually increased after cessation of IH and reached 55 ± 15% above the baseline (n = 7, p < 0.05) whereas the burst rate of PNA did not change. Qualitatively similar but significantly attenuated response (16 ± 8%) was observed in orexin neuron-ablated mice. SHE did not affect amplitude nor frequency in both animals. We conclude that orexin contributes to eliciting phrenic LTF at least in part in mice. This study also showed, for the first time, phrenic LTF following IH in WT mice. Characteristics of phrenic and ventilatory LTF in mice were similar to those in rats.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 168, Issue 3, 30 September 2009, Pages 295–302
نویسندگان
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