کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2848010 1167400 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Time-dependent adaptation in the hemodynamic response to hypoxia
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Time-dependent adaptation in the hemodynamic response to hypoxia
چکیده انگلیسی

In rats, acute exposure to hypoxia causes a decrease in mean arterial pressure (MAP) caused by a predominance of hypoxic vasodilation over chemoreflex-induced vasoconstriction. We previously demonstrated that exposure to chronic intermittent hypoxia (CIH) impairs hypoxic vasodilation in isolated resistance arteries; therefore, we hypothesized that the acute systemic hemodynamic responses to hypoxia would be altered by exposure to CIH. To test this hypothesis, rats were exposed to CIH for 14 days. Heart rate (HR) and MAP were monitored by telemetry. On the first day of CIH exposure, acute episodes of hypoxia caused a decrease in MAP (−9 ± 5 mmHg) and an increase in HR (+45 ± 4 beats/min). On the 14th day of CIH exposure the depressor response was attenuated (−4 ± 1 mmHg; 44% of the day 1 response) and the tachycardia was enhanced (+68 ± 2 beats/min; 151% of the day 1 response). The observed time-dependent modulation of the acute hemodynamic responses to hypoxia may reflect important changes in neurocirculatory regulation that contribute to CIH-induced hypertension.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 165, Issue 1, 1 January 2009, Pages 90–96
نویسندگان
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