کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2848136 1571349 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The mechanics of airway closure
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
The mechanics of airway closure
چکیده انگلیسی

We describe how surface-tension-driven instabilities of the lung’s liquid lining may lead to pulmonary airway closure via the formation of liquid bridges that occlude the airway lumen. Using simple theoretical models, we demonstrate that this process may occur via a purely fluid-mechanical “film collapse” or through a coupled, fluid-elastic “compliant collapse” mechanism. Both mechanisms can lead to airway closure in times comparable with the breathing cycle, suggesting that surface tension is the primary mechanical effect responsible for the closure observed in peripheral regions of the human lungs. We conclude by discussing the influence of additional effects not included in the simple models, such as gravity, the presence of pulmonary surfactant, respiratory flow and wall motion, the airways’ geometry, and the mechanical structure of the airway walls.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 163, Issues 1–3, 30 November 2008, Pages 214–221
نویسندگان
, , ,