کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2848158 | 1167407 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mechanical sensitivity of carotid body glomus cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
فیزیولوژی
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چکیده انگلیسی
Cultured glomus cells from rat carotid bodes were prepared for optical studies of intracellular calcium using the Fura-2 dye. The baseline calcium had a mean of about 40 nM showing either a relatively steady level or large calcium spikes. Some cells did not show measurable levels of [Ca2+]i. Stirring the fluid bathing the cultures induced large increases in [Ca2+]i which were abolished when the bathing medium had zero Ca2+ and EGTA. It is concluded that glomus cells respond to mechanical stimulation when directly exposed to this stimulus and are not protected by supporting structures. It is unknown if the electrical properties of these cells are also affected by mechanical challenges.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 161, Issue 2, 30 April 2008, Pages 210–213
Journal: Respiratory Physiology & Neurobiology - Volume 161, Issue 2, 30 April 2008, Pages 210–213
نویسندگان
Veronica Abudara, Carlos Eyzaguirre,