کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2848248 | 1167414 | 2007 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Airway nociceptors activated by pro-inflammatory cytokines Airway nociceptors activated by pro-inflammatory cytokines](/preview/png/2848248.png)
The present studies evaluate whether the vagus nerves link the lungs’ immune and neural systems by transmitting information through pulmonary nociceptors. Single unit activities from pulmonary nociceptors [C fiber receptors (CFRs) and high threshold Aδ fiber receptors (HTARs)] were recorded from the cervical vagus nerve in anesthetized, open-chest, and mechanically ventilated rabbits. Interleukin1β was then injected into the nociceptor field (IL-1β, 10 μg/ml, 20 μl). Both CFRs and HTARs were stimulated by the local injection; their activities increased from 0.2 ± 0.1 to 1.8 ± 0.5 imp/s (n = 10; p < 0.01), and from 0.2 ± 0.1 to 1.1 ± 0.1 imp/s, respectively (n = 6; p < 0.01). These increases were greatly attenuated by simultaneous administration of IL-1β with IL-1ra, a natural IL-1 receptor antagonist. The nociceptors were not stimulated by local injection of normal saline. Our data demonstrate that nociceptors can be activated by pro-inflammatory cytokines and support the hypothesis that airway nociceptors transmit immune signals from the lung to the brain.
Journal: Respiratory Physiology & Neurobiology - Volume 156, Issue 2, 14 May 2007, Pages 116–119