کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2848248 1167414 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Airway nociceptors activated by pro-inflammatory cytokines
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Airway nociceptors activated by pro-inflammatory cytokines
چکیده انگلیسی

The present studies evaluate whether the vagus nerves link the lungs’ immune and neural systems by transmitting information through pulmonary nociceptors. Single unit activities from pulmonary nociceptors [C fiber receptors (CFRs) and high threshold Aδ fiber receptors (HTARs)] were recorded from the cervical vagus nerve in anesthetized, open-chest, and mechanically ventilated rabbits. Interleukin1β was then injected into the nociceptor field (IL-1β, 10 μg/ml, 20 μl). Both CFRs and HTARs were stimulated by the local injection; their activities increased from 0.2 ± 0.1 to 1.8 ± 0.5 imp/s (n = 10; p < 0.01), and from 0.2 ± 0.1 to 1.1 ± 0.1 imp/s, respectively (n = 6; p < 0.01). These increases were greatly attenuated by simultaneous administration of IL-1β with IL-1ra, a natural IL-1 receptor antagonist. The nociceptors were not stimulated by local injection of normal saline. Our data demonstrate that nociceptors can be activated by pro-inflammatory cytokines and support the hypothesis that airway nociceptors transmit immune signals from the lung to the brain.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 156, Issue 2, 14 May 2007, Pages 116–119
نویسندگان
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