کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2848341 1571352 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Helium–oxygen ventilation in the presence of expiratory flow-limitation: A model study
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Helium–oxygen ventilation in the presence of expiratory flow-limitation: A model study
چکیده انگلیسی

A comparison between air and heliox (80% helium–20% oxygen) ventilation was performed using a mathematical, non-linear dynamic, morphometric model of the respiratory system. Different obstructive conditions, all causing expiratory flow limitation (EFL), were simulated during mechanical ventilation to evaluate and interpret the effects of heliox on tidal EFL and dynamic hyperinflation. Relative to air ventilation, intrinsic positive end-expiratory pressure did not change with heliox if the obstruction was limited to the peripheral airways, i.e. beyond the seventh generation. When central airways were also involved, heliox reduced dynamic hyperinflation (DH) if the flow-limiting segment remained in the fourth to seventh airway generation during the whole expiration, but produced only minor effects if, depending on the contribution of peripheral to total apparent airway resistance, the flow-limiting segment moved eventually to the peripheral airways. In no case did heliox abolish EFL occurring with air ventilation, indicating that any increase in driving pressure would be without effect on DH. Hence, to the extent that chronic obstructive pulmonary disease (COPD) affects primarily the peripheral airways, and causes EFL through the same mechanisms operating in the model, heliox administration should not be expected to appreciably reduce DH in the majority of COPD patients who are flow-limited at rest.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 157, Issues 2–3, 1 August 2007, Pages 326–334
نویسندگان
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