کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2848597 1571355 2006 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of nicotine on rat sternohyoid muscle contractile properties
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Effects of nicotine on rat sternohyoid muscle contractile properties
چکیده انگلیسی

Obstructive sleep apnoea (OSA) is a major clinical disorder characterised by recurring episodes of pharyngeal collapse during sleep. At present, there remains no satisfactory treatment for OSA. Pharmacological therapies as a potential treatment for the disorder are an attractive option and include agents that increase the contractility of the pharyngeal muscles. The aim of the present study was to examine the effects of nicotine on upper airway muscle contractile properties.In vitro isometric contractile properties were determined using strips of rat sternohyoid muscle in physiological salt solution containing nicotine (0–100 μg/ml) at 25 °C. Isometric twitch and tetanic tension, contraction time, half-relaxation time and tension–frequency relationship were determined by electrical field stimulation with platinum electrodes. Fatigue was induced by stimulation at 40 Hz with 300 ms trains at a frequency of 0.5 Hz for 5 min.Nicotine at a concentration of 1 μg/ml was associated with a significant increase in sternohyoid muscle specific tension compared to control data. Dose-dependent increases in contractile tension were not observed. Nicotine had effects on tension–frequency relationship and endurance properties of the sternohyoid muscle at some but not all doses. A leftward shift in the tension–frequency relationship was observed at low stimulus frequencies (20–30 Hz) for nicotine at a concentration of 1 and 5 μg/ml and a significant increase in fatigue resistance was observed with nicotine at a concentration of 10 μg/ml.As fatigue of the upper airway muscles has been implicated in obstructive airway conditions, a pharmacological agent that improves muscle endurance may prove useful as a potential treatment for such disorders. Therefore, further studies of the effects of nicotinic agonists on upper airway function are warranted.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 150, Issues 2–3, 28 February 2006, Pages 200–210
نویسندگان
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