کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2848666 1167435 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Gap junction blockade does not alter eupnea or gasping in the juvenile rat
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Gap junction blockade does not alter eupnea or gasping in the juvenile rat
چکیده انگلیسی

The role of gap junctions in the brainstem respiratory control system is ambiguous. In the present study, we used juvenile rats to determine whether blocking gap junctions altered eupnea or gasping in the in situ, arterially perfused rat preparation. Blockade of gap junctions with 100 μM carbenoxolone or 300 μM octanol did not produce any consistent changes in the timing or amplitude of integrated phrenic discharge or in the peak frequency in the power spectrum of phrenic nerve discharge during eupnea or ischemic gasping beyond those changes seen in time-control animals. These findings do not rule out a role for gap junctions in the expression of eupnea or gasping, but they do demonstrate that these intermembrane channels are not obligatory for either rhythm to occur.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 152, Issue 1, May 2006, Pages 51–60
نویسندگان
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