Integrated functional nanocolloids covered with artificial cell membranes for biomedical applications

SummaryThe functionality of nanocolloids used in biomedical applications are subject to strong interference arising from significant interactions with biological components such as proteins and cells. Among the known examples of surface treatment of nanocolloids, the construction of an artificial cell membrane structure based on phospholipid polymers has proven effective in preventing the occurrence of biological reactions at the surface. Furthermore, certain bioactive molecules can be immobilized on the surface of the phospholipid polymer platform to generate bioaffinity for other biomolecules. This review describes preparation and characterization of integrated functional nanocolloids covered by artificial cell membrane structures and their performance in biomedical applications.

Figure optionsDownload high-quality image (147 K)Download as PowerPoint slideResearch highlights▶ Nanocolloids covered with phosphorylcholine (PC) groups can be used for biomedical applications. ▶ The use of amphiphilic phospholipid polymers is effective as nanocolloids. ▶ Bioactive molecules-immobilized the PC platform are applied to targeted gene and drug delivery. ▶ Cellular uptake of quantum dots can be controlled by functionalization with phospholipid polymer.