کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
328799 1433660 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A TAP2 genotype associated with Alzheimer's disease in APOE4 carriers
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
A TAP2 genotype associated with Alzheimer's disease in APOE4 carriers
چکیده انگلیسی

Sporadic Alzheimer's disease (AD) appears to be the consequence of the interaction between combinations of genes and environmental factors. Binding with the transporter associated with antigen processing (TAP) is thought to be the main way in which herpes simplex virus type 1 (HSV-1) evades immune surveillance. Several TAP gene polymorphisms were examined and a TAP2 SNP (rs241448) associated with AD found in two independent case–control samples, especially in carriers of the APOE4 allele. These findings are consistent with the hypothesis that human genetic variants facilitating the access of HSV-1 to the brain might result in susceptibility to AD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 28, Issue 4, April 2007, Pages 519–523
نویسندگان
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