کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
329124 1433601 2011 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Verbal memory impairment in subcortical ischemic vascular disease: A descriptive analysis in CADASIL
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Verbal memory impairment in subcortical ischemic vascular disease: A descriptive analysis in CADASIL
چکیده انگلیسی

In the elderly, the high prevalence of Alzheimer's disease neuropathology presents a major challenge to the investigation of memory decline in common diseases such as small vessel disease. CADASIL represents a unique clinical model to determine the spectrum of memory impairment in subcortical ischemic vascular dementia (SIVD). One hundred and forty CADASIL patients underwent detailed clinical, neuropsychological and imaging analyses. The Free and Cued Selective Reminding Test was used as a measure of verbal memory. Forty-four out of 140 CADASIL patients (31.4%) presented with memory impairment according to this test. Eight out of 44 (18.2%) subjects with memory impairment matched the definition of the amnestic syndrome of hippocampal type. While alterations in spontaneous recall were related to the severity of subcortical ischemic lesions, the profile of memory impairment, particularly the sensitivity to cueing was found related to other factors such as hippocampal atrophy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 32, Issue 12, December 2011, Pages 2172–2182
نویسندگان
, , , , , , , , , , , , , ,