کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
329537 1433667 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cerebrospinal fluid tau and β-amyloid in Alzheimer patients, disease controls and an age-matched random sample
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Cerebrospinal fluid tau and β-amyloid in Alzheimer patients, disease controls and an age-matched random sample
چکیده انگلیسی

We prospectively evaluated the diagnostic accuracy of cerebrospinal fluid (CSF)-β-amyloid1–42 (Aβ42), -total-tau (tau) and -phosphorylated-tau181 (p-tau181) as measured by sandwich ELISAs in the clinical routine of a community state hospital to discriminate between patients with Alzheimer's disease (AD), healthy controls (HC), non-AD-dementias, a group composed of various psychiatric disorders (non-AD-dementias, mental diseases) and an age-matched random sample (RS) (total N = 219).By comparing patients with AD to HC as reference, tau revealed sensitivity (sens)/specificity (spec) of 88%/80%, p-tau181 88%/80%, tau/Aβ42-ratio 81%/85% and phospho-tau181/Aβ42-ratio 81%/78%. Discriminative power between HC and all dementias under investigation was estimated lower for tau (78%/77%) and p-tau181 (73%/79%). Relative to patients with AD, ROC analysis for the RS revealed highest sens/spec for p-tau181 (79%/77%) and p-tau181/Aβ42 ratio (78%/75%). Differentiation between AD versus a group made of patients with various psychiatric disorders was optimised by using CSF-p-tau181 (80%/77%).Under clinical routine conditions current CSF-biomarkers show a substantial capacity to discriminate between AD and HC as reference and to mark off AD patients from RS and heterogeneous diagnostic groups composed of non-AD dementias and other psychiatric conditions. Despite a residual substantial overlap between the groups, we conclude that current CSF markers are well suited to support AD-related diagnostic procedures in every-day clinics.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 27, Issue 9, September 2006, Pages 1202–1211
نویسندگان
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