کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
330310 1433636 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
VDR gene variants associate with cognitive function and depressive symptoms in old age
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
VDR gene variants associate with cognitive function and depressive symptoms in old age
چکیده انگلیسی

Vitamin D has been recently implicated in brain function. Our objective was to test whether genetic variance in the vitamin D receptor (VDR) gene is associated with cognitive functioning and depressive symptoms in old age. The study was carried out in the prospective population-based Leiden 85-plus Study. All 563 participants of the study were genotyped for Cdx-2, FokI, BsmI, ApaI and TaqI polymorphisms in the VDR gene. Our data revealed an overall worse performance on tests measuring cognitive functioning for carriers of BsmI (p = 0.013) and TaqI (p = 0.004) polymorphisms, and of haplotype 2 (BAt) (p = 0.004). In contrast, carriers of ApaI variant-allele and of haplotype 1 (baT) had better cognitive functioning together with less depressive symptoms. These associations could not be explained by differences in calcium levels, and by selective survival, since no associations between the VDR gene variants and calcium levels and mortality were observed. In conclusion, our results show that genetic variance in the VDR gene influences the susceptibility to age-related changes in cognitive functioning and in depressive symptoms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 30, Issue 3, March 2009, Pages 466–473
نویسندگان
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