کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
330495 | 1433664 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Peripheral clearance of amyloid β peptide by complement C3-dependent adherence to erythrocytes
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Peripheral clearance of amyloid β peptide by complement C3-dependent adherence to erythrocytes Peripheral clearance of amyloid β peptide by complement C3-dependent adherence to erythrocytes](/preview/png/330495.png)
چکیده انگلیسی
Brain deposits of amyloid β peptide (Aβ) have been a diagnostic hallmark of Alzheimer's disease (AD) for nearly a century. Recent studies have demonstrated that Aβ is also present in peripheral blood. Here, we present evidence that circulating Aβ42 is subject to complement C3b-dependent adherence to complement receptor 1 (CR1) on erythrocytes, a classical set of mechanisms by which pathogens and proteins recognized as foreign are cleared from the bloodstream. Levels of Aβ42 targeted by this pathway differ significantly in AD compared to mild cognitive impairment and nondemented elderly controls.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 27, Issue 12, December 2006, Pages 1733–1739
Journal: Neurobiology of Aging - Volume 27, Issue 12, December 2006, Pages 1733–1739
نویسندگان
Joseph Rogers, Rena Li, Diego Mastroeni, Andrew Grover, Brian Leonard, Geoffrey Ahern, Phillip Cao, Heather Kolody, Linda Vedders, William P. Kolb, Marwan Sabbagh,