کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
331185 1433650 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Automated cortical thickness measurements from MRI can accurately separate Alzheimer's patients from normal elderly controls
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Automated cortical thickness measurements from MRI can accurately separate Alzheimer's patients from normal elderly controls
چکیده انگلیسی

We investigated the potential of fully automated measurements of cortical thickness to reproduce the clinical diagnosis in Alzheimer's Disease (AD) using 19 patients and 17 healthy controls. Thickness maps were analyzed using three different discriminant techniques to separate patients from controls. All analyses were performed using leave-one-out cross-validation to avoid overtraining of the discriminants. The results show regionally variant patterns of discrimination ability, with over 90% accuracy obtained in the medial temporal lobes and other limbic structures. Multivariate discriminant analysis produced 100% accuracy with six different combinations, all involving the parahippocampal gyrus. We therefore propose automated measurements of cortical thickness as a tool to improve the clinical diagnosis of probable AD, as well as a research method to gain unique insight into the etiology of cortical pathology in the disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 29, Issue 1, January 2008, Pages 23–30
نویسندگان
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