Case-based reasoning investigation of therapy inefficacy

ISOR is a case-based reasoning system for long-term therapy support in the endocrine domain and in psychiatry. ISOR performs typical therapeutic tasks, such as computing initial therapies, initial dose recommendations and dose updates. ISOR deals especially with situations where therapies become ineffective. Causes for inefficacy have to be found and better therapy recommendations should be computed. In addition to former already solved cases, ISOR uses further knowledge forms, especially medical histories of query patients themselves and prototypes. Furthermore, the knowledge base consists of therapies, conflicts, instructions, etc. So, different forms and steps of retrieval are performed, while adaptation occurs as an interactive dialog with the user.