کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
417127 | 681454 | 2009 | 15 صفحه PDF | دانلود رایگان |
Case–control association studies using unrelated cases and controls may suffer from potential confounding due to population stratification. Bias and variance distortion caused by population stratification in the commonly used allele-based tests can considerably inflate the Type I error rate. It is shown that the bias vanishes in the absence of disease rate heterogeneity. If only population stratification exists, a proper estimate of the variance of the allele-based test statistic is developed. Using this estimated variance yields a valid Type I error. However, when the frequencies of the allele under study and the disease rates differ among the subpopulations, it is difficult to correct for this bias. Explicit expressions for the excess false positive rate (EFPR) of the test due to bias and variance distortion are derived. It turns out that the bias created when both population stratification and disease rate heterogeneity are present usually has a greater effect on the EFPR than variance distortion. Comprehensive simulation studies strongly support these results.
Journal: Computational Statistics & Data Analysis - Volume 53, Issue 5, 15 March 2009, Pages 1767–1781