کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
417954 681595 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Optimization in a multivariate generalized linear model situation
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر نظریه محاسباتی و ریاضیات
پیش نمایش صفحه اول مقاله
Optimization in a multivariate generalized linear model situation
چکیده انگلیسی

The purpose of this article is to find the settings of the factors which simultaneously optimize several mean responses in a multivariate generalized linear model (GLM) environment. The generalized distance approach, initially developed for the simultaneous optimization of several linear response surface models, is adapted to this multivariate GLM situation. An application of the proposed methodology is presented in the special case of a bivariate binary distribution resulting from a drug testing experiment concerning two responses, namely, the efficacy and toxicity of a particular drug combination. One of the objectives of this application is to find the dose levels of two drugs that simultaneously maximize their therapeutic effect and minimize any possible toxic effects. A second application is presented in the case of a multivariate gamma distribution.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computational Statistics & Data Analysis - Volume 52, Issue 10, 15 June 2008, Pages 4625–4634
نویسندگان
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