کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
418277 | 681626 | 2007 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Identification of the minimum effective dose for right-censored survival data
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی کامپیوتر
نظریه محاسباتی و ریاضیات
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Identification of the minimum effective dose for right-censored survival data Identification of the minimum effective dose for right-censored survival data](/preview/png/418277.png)
چکیده انگلیسی
In this paper, we consider identifying the minimum effective dose (MED) in a dose–response study when survival data are subject to random right-censorship, where the MED is defined to be the smallest dose level under study that has survival advantage over the zero-dose control. To this end, we suggest single-step-down testing procedures based on three different types of weighted logrank statistics, respectively. The comparative results of a Monte Carlo error rate and power/bias study for a variety of survival and censoring distributions are then presented and discussed. The application of the testing procedures for identifying the MED is finally illustrated by using a numerical example of prostate cancer data.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computational Statistics & Data Analysis - Volume 51, Issue 6, 1 March 2007, Pages 3213–3222
Journal: Computational Statistics & Data Analysis - Volume 51, Issue 6, 1 March 2007, Pages 3213–3222
نویسندگان
Yuh-Ing Chen, Yu-Mei Chang,