کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
418739 681715 2009 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A new constraint-based description of the steady-state flux cone of metabolic networks
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر نظریه محاسباتی و ریاضیات
پیش نمایش صفحه اول مقاله
A new constraint-based description of the steady-state flux cone of metabolic networks
چکیده انگلیسی

Metabolic pathway analysis is an important area in computational biology, which has received considerable attention in the recent past. The set of all possible flux distributions over a metabolic network at steady state defines a polyhedral cone, the steady-state flux cone. Two major approaches exist to characterize this cone: elementary flux modes and extreme pathways. Both use an inner description of the flux cone, which is based on sets of generating vectors. The number of these generators may be very large even for small networks. This limits the practical applicability of these methods.We present a new constraint-based approach to metabolic pathway analysis which uses an outer description of the flux cone, based on sets of non-negativity constraints. These can be identified with irreversible reactions and thus have a direct biochemical interpretation. The resulting description of the flux cone is minimal and unique. Furthermore, it satisfies a simplicity condition similar to the one that holds for elementary flux modes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Discrete Applied Mathematics - Volume 157, Issue 10, 28 May 2009, Pages 2257–2266
نویسندگان
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