کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4372500 1617100 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Heterogeneity in antibody range and the antigenic drift of influenza A viruses
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک بوم شناسی، تکامل، رفتار و سامانه شناسی
پیش نمایش صفحه اول مقاله
Heterogeneity in antibody range and the antigenic drift of influenza A viruses
چکیده انگلیسی

In this paper we explore the consequences of a heterogeneous immune response in individuals on the evolution of a rapidly mutating virus. We show that several features of the incidence and phylogenetic patterns typical of influenza A may be understood in this framework. In our model, limited diversity and rapid drift of the circulating viral strains result from the interplay of two interacting subpopulations with different types of immune response, narrow or broad, upon infection. The subpopulation with the narrow immune response acts as a reservoir where consecutive mutations escape immunity and can persist. Strains with a number of accumulated mutations escape immunity in the other subpopulation as well, causing larger epidemic peaks in the whole population, and reducing strain diversity. Overall, our model produces a modulation of epidemic peak heights and patterns of antigenic drift consistent with reported observations, suggesting an underlying mechanism for the evolutionary epidemiology of influenza, in particular, and other infectious diseases, more generally.


► Model of influenza transmission in population heterogeneous for antibody response.
► Individual-based model with monoclonal immunity until age 5, polyclonal thereafter.
► Model simulations reproduce patterns of influenza epidemiology and evolution.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ecological Complexity - Volume 14, June 2013, Pages 157–165
نویسندگان
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