Nanaomycin A methyl ester, an actinomycete metabolite: Algicidal activity and the physiological response of Microcystis aeruginosa

► Nanaomycin A methyl ester, NAME, can inhibit M. aeruginosa growth (EC50 = 2.97 mg L−1). ► NAME induces M. aeruginosa cell enlargement due to inhibition of cell division. ► NAME induces ROS to disturb M. aeruginosa physiological process and growth. ► Chl-fluorescence is a sensitive endpoint to assay NAME eco-toxicity on cyanobacteria.