Dibutyltin (DBT) an endocrine disrupter in zebrafish

► DBT is an endocrine disruptor in zebrafish. ► In vivo, DBT exposure decreases zfCYP19a, zfERβ1 and FST mRNA in the gonads. ► In vitro, DBT exposure inhibits testosterone induced luciferase activity. ► In vitro, DBT exposure increases ethinylestradiol induced luciferase activity. ► DBT's MOA is complex and may be due to the metabolism of DBT to MBT.