کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
443383 692714 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Arylhydrazone derivatives of naproxen as new analgesic and anti-inflammatory agents: Design, synthesis and molecular docking studies
ترجمه فارسی عنوان
مشتقات آریل هیدرازن ناپروکسن به عنوان عوامل ضد درد و ضد التهابی جدید: مطالعات طراحی، سنتز و تکمیل مولکولی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی تئوریک و عملی
چکیده انگلیسی


• Please check the hierarchy of the section headings and amend if necessary.
• Their binding affinities to COX enzymes were evaluated by docking studies.
• The docking results showed that the compounds bind more selectively to COX-2.
• The designed compounds were synthesized and their pharmacological activities were evaluated.

A series of new arylidenehydrazone derivatives of naproxen were synthesized and evaluated for their analgesic and anti-inflammatory activities. Some of the synthesized analogues showed comparable activities when compared against naproxen for their analgesic and anti-inflammatory properties. 2-(6-methoxy-2-naphthyl)-N′-[(pyridine-4-yl)methylene]propanoic acid hydrazide 4j was found to be the most active analgesic agent. 2-(6-methoxy-2-naphthyl)-N′-[4-nitrobenzylidene]propanoic acid hydrazide 4g showed highest anti-inflammatory activity in comparison to the naproxen. Molecular modeling study of the synthesized compounds suggested that the designed molecules were well located and bound to the COX-1 and COX-2 active sites. Compound 4g showed the highest selectivity for COX-2 (RCOX-2/COX-1 = 1.94) and higher affinity rather than naproxen in COX-2 active site (RCOX-2/naproxen = 1.28). Moreover, the structural analyses confirmed that the E-ap rotamer is the preferred structure for the arylidenehydrazone derivatives.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Graphics and Modelling - Volume 67, June 2016, Pages 127–136
نویسندگان
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