کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
444732 693036 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structural-symmetry-related sequence patterns of the proteins of beta-propeller family
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
Structural-symmetry-related sequence patterns of the proteins of beta-propeller family
چکیده انگلیسی

It is still not very clear to what extent and how does the amino acid sequences of proteins determine their tertiary structures. In this paper, we report our investigations of the sequence–structure relations of the proteins in the beta-propeller fold family, which adopt highly symmetrical tertiary structures while their sequences appear “random”. We analyzed the amino acid sequences by using a similarity matrix plus Pearson correlation method and found that the sequences can show the same symmetries as their tertiary structures only if we deduce the conditions of sequence similarity. This suggests that some key residues may play an important role in the formation of the tertiary structures of these proteins.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Graphics and Modelling - Volume 26, Issue 5, January 2008, Pages 829–833
نویسندگان
, , ,