Mating induces developmental changes in the insect female reproductive tract

• Unmated mature female reproductive tract is ‘poised’ for a rapid response to mating.
• Mating triggers a second phase of maturation of the female reproductive tract.
• This rapid switch may evolve as a mechanism that optimizes reproductive capacity.

In response to mating, the Drosophila female undergoes a series of rapid molecular, morphological, behavioral and physiological changes. Studies in Drosophila and other organisms have shown that stimuli received during courtship and copulation, sperm, and seminal fluid are needed for the full mating response and thus reproductive success. Very little is known, however, about how females respond to these male-derived stimuli/factors at the molecular level. More specifically, it is unclear what mechanisms regulate and mediate the mating response, how the signals received during mating are integrated and processed, and what network of molecules are essential for a successful mating response. Moreover, it is yet to be determined whether the rapid transition of the reproductive tract induced by mating is a general phenomenon in insects. This review highlights current knowledge and advances on the developmental switch that rapidly transitions the female from the ‘unmated’ to ‘mated’ state.