Circadian regulation of learning and memory

• The circadian clock coordinates behavior, learning, and memory, with environmental cycles.
• The circadian system regulates memory acquisition in response to classical conditioning.
• Circadian phase can be used as a contextual cue for memory recall.

The study of the relationship between biological clocks and learning and memory in insects goes back to work on Zeitgedachtnis (time memory) in bees originating in the early 1900s when it was shown that bees were able to remember the time of day a specific food source was available. More recent work has expanded on the role of circadian phase in memory acquisition, consolidation, and recall in additional insect species. The results show that the circadian system can modulate the ability of individuals to acquire memories or the ability to retrieve memories; however, questions remain both about the mechanisms by which the circadian system regulates these processes and about the functional/adaptive significance of this novel feature of insect circadian organization.