Characterization of phospholipid hydroperoxide glutathione metabolizing peroxidase (gpx4) isoforms in Coho salmon olfactory and liver tissues and their modulation by cadmium

► Cloned two gpx4 isoforms (gpx4a and gpx4b) from the Coho salmon peripheral olfactory system. ► Developed qPCR assays for a comprehensive analysis of gpx4 expression in 10 tissues. ► High initial rates of GPx4 enzymatic activity in Coho olfactory and liver tissues. ► Examined the effect of cadmium on gpx4 expression in olfactory and liver tissues.