Sublethal responses to ammonia exposure in the endangered delta smelt; Hypomesus transpacificus (Fam. Osmeridae)

► We examine transcriptional changes in juvenile delta smelt to ammonia exposure. ► Sublethal concentrations predominantly affect the regulation of genes associated with cell membrane integrity, neurological and muscular function. ► Effects on cell membrane destabilization suggest potential effects on membrane permeability enhancing multiple-contaminant exposure.