کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4529823 | 1625982 | 2011 | 7 صفحه PDF | دانلود رایگان |
P450 aromatase catalyses the conversion of C19 androgens to C18 estrogens which is thought to be essential for the regulation of the reproductive function. In this study, brain aromatase activity (AA) was measured monthly over a reproductive cycle in wild roach (Rutilus rutilus) sampled in a reference site in Normandy. AA peaked during the breeding season, reaching 35 fmol mg−1 min−1 in both male and female fish, and was low during the rest of the year except for a significant rise in October. AA was correlated with ovary maturation (measured either as gonado-somatic index or by histological analysis of the gonads) and plasma sex-steroid levels (11-ketotestosterone in males and 17-β-estradiol in females). Measurements of AA in polluted sites showed that activity was significantly upregulated in sites with fish showing high levels of plasma vitellogenin and large proportion of intersexuality (20–50%) thus suggesting the occurrence of estrogenic compounds and their involvement in AA modulation.
► We investigated seasonal variations of brain P450 aromatase activity in roach.
► Brain AA was correlated with gonad maturation and plasma steroid levels during reproduction.
► P450 aromatase activity was also assessed in fish from polluted sites.
► Brain AA was modulated in exposed fish and associated with other endocrine alterations.
Journal: Aquatic Toxicology - Volume 105, Issues 3–4, October 2011, Pages 378–384