کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4629171 | 1340574 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Optimal multi-therapeutic HIV treatment using a global optimal switching scheme
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
ریاضیات کاربردی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Optimal multi-therapeutic HIV treatment using a global optimal switching scheme Optimal multi-therapeutic HIV treatment using a global optimal switching scheme](/preview/png/4629171.png)
چکیده انگلیسی
The problem of multi-therapeutic HIV treatment is posed in this study as a switching problem to find the optimal switching time between the different therapies. To solve the optimal switching problem with nonlinear subsystems an algorithm is developed for learning the cost-to-go as a function versus different switching times and different initial conditions. Once the function is obtained in a closed form, finding optimal switching time for every given initial condition reduces to a function optimization. Through numerical simulations of a model for the HIV problem, the proposed algorithm is shown to be a useful tool for solving this class of problems.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Mathematics and Computation - Volume 219, Issue 14, 15 March 2013, Pages 7872-7881
Journal: Applied Mathematics and Computation - Volume 219, Issue 14, 15 March 2013, Pages 7872-7881
نویسندگان
Ali Heydari, S.N. Balakrishnan,