Computer controlled sequential simulation method: Reconsidering evaluation of measurements from frequently sampled intravenous glucose tolerance test

This work describes quantification of regulatory mechanisms glucose–insulin, using data from a frequently sampled intravenous glucose tolerance test (FSIVGTT) and a mechanistically motivated model with time delays. FSIVGTT was performed on 14 young healthy volunteers. The constructed model computationally takes into account the form of the short-time glucose infusion used. Estimated model parameters are used to derive relationships quantifying the following mechanisms of regulatory systems glucose–insulin of the volunteers enrolled: (1) glucose uptake by body cells; (2) cessation (suppression) of glucose output from liver; (3) glucose clearance. The model presented correctly approximates initial peaks and subsequent waves in plasma glucose concentration–time profiles after the glucose infusion. These results indicate that the model presented is an appropriate tool for assessing glucose behavior during a FSIVGTT.