کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
467849 698129 2013 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Algorithms for modeling structural changes in human chromosomes
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر علوم کامپیوتر (عمومی)
پیش نمایش صفحه اول مقاله
Algorithms for modeling structural changes in human chromosomes
چکیده انگلیسی

Human cytogenetics is the study of chromosomes (typically at mitotic metaphase). The study of chromosomes has recently become integrated with molecular biology and genomics. Thus, it is an important part of genetics education. However, it is time consuming to train students and clinical technologists to recognize patterns of G-banded human chromosomes because of the dynamic nature of G-band resolutions in different metaphase spreads. Moreover, there are limited resources to obtain the images of abnormal chromosomes. We present in this paper an advanced version of computer based interactive tutorial program capable of simulating chromosome abnormalities, altering chromosome shapes, and manipulating G-band resolutions for human cytogenetic seduction. By simulating chromosomes using digital image processing and pattern recognition, the versatile software, together with various strategies such as website links and dialogs, will provide students with a virtual learning environment for self-practicing and testing, thus transforming the traditionally dry and ineffective approach into an exciting and efficient learning process.


► Efficient algorithms for modeling structural changes in human G-banded chromosomes have been developed.
► The simulated chromosome structural changes include deletion, duplication, inversion, and translocation.
► The software, together with our recently developed interactive karyotyping program, provides an effective tool for human cytogenetics education.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computer Methods and Programs in Biomedicine - Volume 110, Issue 2, May 2013, Pages 171–182
نویسندگان
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