کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
469310 | 698306 | 2007 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
np1: A computer program for dose escalation strategies in phase I clinical trials
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی کامپیوتر
علوم کامپیوتر (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: np1: A computer program for dose escalation strategies in phase I clinical trials np1: A computer program for dose escalation strategies in phase I clinical trials](/preview/png/469310.png)
چکیده انگلیسی
The continual reassessment method is a recommended dose escalation design for including patients in phase I clinical trials designed to estimate the maximum tolerated dose. However, for a particular trial, the implementation of these methods requires extensive computer programming. Standard 3 + 3 designs do not require this, but have shown to possess poor statistical properties. np1 is a user friendly computer program which has implemented two continual reassessment methods for simulating and conducting a phase I clinical trial. Several options allow the user to investigate operating characteristics under various scenario.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computer Methods and Programs in Biomedicine - Volume 88, Issue 1, October 2007, Pages 8–17
Journal: Computer Methods and Programs in Biomedicine - Volume 88, Issue 1, October 2007, Pages 8–17
نویسندگان
Andrew Kramar, Nadine Houédé, Xavier Paoletti,