کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
469792 698355 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
GRAT—genome-scale rapid alignment tool
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر علوم کامپیوتر (عمومی)
پیش نمایش صفحه اول مقاله
GRAT—genome-scale rapid alignment tool
چکیده انگلیسی

Modern alignment methods designed to work rapidly and efficiently with large datasets often do so at the cost of method sensitivity. To overcome this, we have developed a novel alignment program, GRAT, built to accurately align short, highly similar DNA sequences. The program runs rapidly and requires no more memory and CPU power than a desktop computer. In addition, specificity is ensured by statistically separating the true alignments from spurious matches using phred quality values. An efficient separation is especially important when searching large datasets and whenever there are repeats present in the dataset. Results are superior in comparison to widely used existing software, and analysis of two large genomic datasets show the usefulness and scalability of the algorithm.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computer Methods and Programs in Biomedicine - Volume 86, Issue 1, April 2007, Pages 87–92
نویسندگان
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