کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4765122 | 1423854 | 2017 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The idiosyncratic drug-induced gene expression changes in HepG2 cells The idiosyncratic drug-induced gene expression changes in HepG2 cells](/preview/png/4765122.png)
The inflammatory stress has been associated with an increase in susceptibility to idiosyncratic drug-induced liver injury (DILI). However, the molecular mechanisms of this inflammation-associated idiosyncratic drug hepatotoxicity remain unknown. We exposed HepG2 cells with high and low doses of three idiosyncratic (I) and three non-idiosyncratic (N) compounds, in the presence (I+ and N+) or absence (Iâ and Nâ) of a cytokine mix for 6, 12 and 24Â h. To investigate the genomeâwide expression patterns, microarray was performed using the Agilent 4Ã44K Whole Human Genome chips. The data presented in this DIB include the expression of genes participating in the ceramide metabolism, ER stress, apoptosis and cell survival pathways. The functions of these genes were illustrated in our associated article (Jiang et al., 2017) [1]. Raw and normalized gene expression data are available through NCBI GEO (accession number GSE102006).
Journal: Data in Brief - Volume 14, October 2017, Pages 462-468