کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4766210 | 1423899 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mitochondria-specific imaging in living cells with two-photon absorption small molecule containing amino groups
ترجمه فارسی عنوان
تصویربرداری اختصاصی میتوکندری در سلول های زنده با مولکول کوچک جذب دو فوتون حاوی گروه های آمینو
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
چکیده انگلیسی
Two-photon fluorescent probes have emerged as promising molecular tools for imaging subcellular organelles. Here, the facile synthesis of three novel nitro molecules (Z1-Z3) with lager two-photon absorption cross-section and three novel amino molecules (L1-L3) based on mitochondrial probes with two-photon absorption are presented. Their photophysical properties have been investigated both experimentally and theoretically. The study of nonlinear optical property revealed that Z1-Z3 possess more excellent two-photon absorption (2PA) cross-section values than L1-L3 and the 2PA cross-section values were enhanced with increasing electron-donating strength of the end group when fixed the opposite group (nitro or amino). Furthermore, in consideration of the water solubility and fluorescent intensity, L1-L3 possessing high specificity for mitochondrial localization were applied to biology, which is advantageous in comparison with commercially available mitochondrial trackers. Due to their low cytotoxicity, these small molecules L1-L3 offer a promising platform to directly monitor mitochondria in living cells and zebra fish.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Dyes and Pigments - Volume 136, January 2017, Pages 473-479
Journal: Dyes and Pigments - Volume 136, January 2017, Pages 473-479
نویسندگان
Rongting Guan, Hui Wang, Qiong Zhang, Jieying Wu, Yupeng Tian,