کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
479372 | 1446209 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A semi-Markov model for patient progression through clinical trials
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی کامپیوتر
علوم کامپیوتر (عمومی)
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Clinical trials constitute large, resource-intensive endeavors for pharmaceutical companies, academic institutions and government agencies. Accounts have estimated the number of patients involved in clinical trials in the US as high as 725,000 patients with costs in excess of $19 billion. Despite the scope of these activities, little has been done by way of a general model to highlight the progression of patients through the various stages of a clinical trial. We present a semi-Markov model that can be used to explore the patient population profile of a clinical trial for arbitrarily many patient classes, trial sites and start-times.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Operational Research - Volume 176, Issue 1, 1 January 2007, Pages 542–549
Journal: European Journal of Operational Research - Volume 176, Issue 1, 1 January 2007, Pages 542–549
نویسندگان
James C. Felli, Wesley H. Anderson, James P. Kremidas, Stephen J. Ruberg,