Montmorillonite K10: An efficient organo heterogeneous catalyst for one-pot synthesis of new N,N′-alkylidene bisamide derivatives under solvent free condition

Montmorillonite K10 clay as an efficient heterogeneous catalyst for the one-pot synthesis of new N,N′-alkylidene bisamide derivatives using phenyl acetylene/1-hexyne, aromatic aldehyde and benzamide/acetamide were taken as starting materials. The desired products were obtained in good to high yields. The assistance of alkynes has been confirmed by using thin layer chromatographic (TLC) studies. All the reactions were done at 100 °C using 0.035 g of catalyst. The developed method is valid for either substituted aldehyde, thus it constitutes a general synthetic method for these kinds of compounds. In all the cases aromatic aldehydes containing electron-withdrawing groups gave shorter time than that with electron-donating groups. The salient features of the present protocol are mild reaction conditions, excellent yields, high atom economy, Eco-friendliness, easy isolation of products, recyclability and reusability of the catalyst.

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