Synthesis and biological evaluation of fluorine substituted pyrazolo[4,3-e][1,2,4]triazines as purine analogues

Some more new fluorine substituted pyrazolo[4,3-e][1,2,4]triazine derivatives (2-5), 7, 10, 14, 17 have been synthesized derived from hydrazinolysis of N-acyl/aroyl/dithioic formamido-2,3-dimethyl-1-phenyl-pyrazolo-5-ones which are obtained from 4-aminoantipyrine 1. The enzymatic assays (cellobaise activity) of the new products have been evaluated.