کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4909364 | 1362617 | 2017 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
New ferrocene modified lawsone Mannich bases with anti-proliferative activity against tumor cells
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: New ferrocene modified lawsone Mannich bases with anti-proliferative activity against tumor cells New ferrocene modified lawsone Mannich bases with anti-proliferative activity against tumor cells](/preview/png/4909364.png)
چکیده انگلیسی
Lawsone (1a) is a known naphthoquinone dye from the Henna plant Lawsonia inermis. Out of a series of four new ferrocene modified Mannich bases of 1a, the 2-pyridyl derivative 2a was distinctly more active than its analogs 2b-d in breast, prostate and pancreatic cancer cells. 2a also exhibited greater antiproliferative effects when compared with the known anticancer active Mannich bases 1b and 1c in the androgen-receptor negative PC-3 prostate and Pgp-expressing KB-V1/Vbl cervix carcinoma cell lines. Compound 2a reached sub-micromolar activities in these aggressive cancer cells and, thus, features a promising drug candidate for the efficient treatment of hormone- or multidrug-resistant cancer types.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Saudi Chemical Society - Volume 21, Issue 1, January 2017, Pages 105-110
Journal: Journal of Saudi Chemical Society - Volume 21, Issue 1, January 2017, Pages 105-110
نویسندگان
Aamir Ahmad, Katharina Mahal, Subhash Padhye, Fazlul H. Sarkar, Rainer Schobert, Bernhard Biersack,