کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4932561 | 1433530 | 2017 | 74 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume
ترجمه فارسی عنوان
منابع قطع ارتباط در پیری شناختی عضلانی: یکپارچگی ماده مغذی مغز، اتصال به عملکرد حالت استراحت، و حجم فوق العاده شدت ماده سفید
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کلمات کلیدی
تصویربرداری رزونانس مغناطیسی، تصویربرداری تانسور نفوذ، شناخت، قشر واسطه
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Age-related decline in fluid cognition can be characterized as a disconnection among specific brain structures, leading to a decline in functional efficiency. The potential sources of disconnection, however, are unclear. We investigated imaging measures of cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume as mediators of the relation between age and fluid cognition, in 145 healthy, community-dwelling adults 19-79Â years of age. At a general level of analysis, with a single composite measure of fluid cognition and single measures of each of the 3 imaging modalities, age exhibited an independent influence on the cognitive and imaging measures, and the imaging variables did not mediate the age-cognition relation. At a more specific level of analysis, resting-state functional connectivity of sensorimotor networks was a significant mediator of the age-related decline in executive function. These findings suggest that different levels of analysis lead to different models of neurocognitive disconnection, and that resting-state functional connectivity, in particular, may contribute to age-related decline in executive function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 54, June 2017, Pages 199-213
Journal: Neurobiology of Aging - Volume 54, June 2017, Pages 199-213
نویسندگان
David J. Madden, Emily L. Parks, Catherine W. Tallman, Maria A. Boylan, David A. Hoagey, Sally B. Cocjin, Lauren E. Packard, Micah A. Johnson, Ying-hui Chou, Guy G. Potter, Nan-kuei Chen, Rachel E. Siciliano, Zachary A. Monge, Jesse A. Honig,